Developmental Androgen Resistance	

	Disorders of androgen action cause several types of male pseudohermaphroditism. In such disorders, testosterone formation and Mullerian regression are normal, and impairment of male development is a result of resistance to androgen action in the target cells. 5a-reductase deficiency is an autosomal recessive disorder characterised by: 
• Severe perineoscrotal hypospadias. 
• A blind vaginal pouch of variable size, opening either into the urogenital sinus or the urethra. 
• Testes with normal epididymides, vasa deferentia, seminal vesicles, and ejaculatory ducts that terminate in the blind-ending vagina. 
• A female habitus without female breast development but with normal axillary and pubic hair. 
• Absence of female urogenital structures. 
• Normal male plasma testosterone. 
• Masculinisation to a variable degree at the time of puberty.